Signals conveyed from one part of the body to another, require the release of chemical messengers (hormones and neurotransmitters) from one set of cells and their action on target cells. The processes by which hormones and neurotransmitters act on target cells require increases in the concentration of calcium ions in the target cell. This is often achieved by calcium entering the cell through channels in the plasma membrane. The aims of this research is to study the physiological functions of these calcium channels, their structures and mechanisms of opening, and how these channels are altered in diseased states.
Steenks M, Baal V, Nieuwenhuijs V, De Bruijn M, Schiesser
M, Teo EH, Callahan T, Padbury RT & Barritt GJ (2010)
Intermittent ischaemia maintains function after ischaemia reperfusion
in steatotic livers. Journal of Hepato-Biliary-Pancreatic
Surgery. 12(4), 250-261
To M-S, Aromataris EC, Castro J, Roberts ML, Barritt GJ and Rychkov GY (2010) Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells. Arch. Biochem. Biophys, 495:152-158
Castro J, Aromataris EC, Rychkov GY and Barritt GJ (2009) A small
component of the endoplasmic reticulum is required for store-operated
Ca2+ channel activation in liver cells: evidence from studies using
TRPV1 and taurodeoxycholic acid. Biochem. J. 418, 553-566
Peters J, Nieuwenhuijs VB, Morphett A, Porte RJ, Padbury RTA
and Barritt GJ (2009) Increasing cycles of intermittent ischemia
can effectively maintain liver function during the acute phase
of ischemia reperfusion injury by promotion of bile flow and reduction
in bile salt toxicity. Dig. Surg. 26, 455-464
de Vries AH, Ponds FAM, Padbury RTA ,Porte RJ, Nieuwenhuijs VB
and Barritt GJ (2009) Influence of estrogen on the early recovery
of hepatobiliary secretory function after ischemia reperfusion
injury in rats. J. Hepatol. 50(Supp
1), S66
Wigg AJ, Barritt GJ, Young GP and Phillips JW (2009) Inhibition
of oxidative stress and apoptosis enables extended maintenance of
integrity and function of isolated hepatocytes in suspension. J.
Gastroenterol. Hepatol.
24, 1082-1088
Schiesser M, Wittert A, Nieuwenhuijs VB, Morphett A, Padbury
RTA and Barritt GJ (2009) Intermittent ischemia but not ischemic
preconditioning is effective in restoring bile flow after ischemia
reperfusion injury in the livers of aged rats. J. Surg. Res.
152, 61-68
Scrimgeour N, Litjens T, Ma L, Barritt GJ and Rychkov TY (2009)
Properties of Orai1 mediated store-operated current depend on the
expression levels of STIM1 and Orai1 proteins. J. Physiol. 587,
2903-2918
Zeile S, Wilson C, Chataway T, Nieuwenhuijs VB, Padbury
RTA and Barritt GJ (2009) Proteomic analysis reveals modulation
of peroxiredoxin 1 following ischemia reperfusion injury of liver. J.
Hepatol. 50(Supp
1), S64
Barritt GJ, Litjens TL, Castro J, Aromataris E and Rychkov GY
(2009) Store- operated Ca2+ channels and microdomains of Ca2+ in
liver cells. Clin.
Exp. Pharmacol. Physiol. 36, 77-83
Barritt GJ, Chen J and Rychkov GY (2008) Ca 2+-permeable channels
in the hepatocyte plasma membrane and their roles in hepatocyte
physiology. Biochem Biophys Acta - Mol Cell Res, 1783,
651-672
Aromataris EC, Castro J, Rychkov GY and Barritt GJ (2008) Store-operated
Ca 2+ channels and stromal interaction molecular 1 (STIM1) are
targets for the actions of bile acids on liver cells. Biochem
Biophys Acta - Mol Cell Res, 1783, 874-885
Khung YL, Barritt G and Voelcker NH (2008) Using continuous porous
silicon gradients to study the influence of surface topography
on the behaviour of neuroblastoma cells. Exper Cell Res, 314,
789-800
Beck B, Bavencoffe A, Bidaux G, Lemonnier L, Thebault S, Shuba
Y, Barritt G, Skryma R and Prevarskaya N (2007)
Prospects for prostate cancer imaging and therapy using high-affinity
TRPM8 activators. Cell
Calcium 41:285-94
Nieuwenhuijs VB, de Bruijn MT, Schiesser M, Morphett A, Padbury
RT, Barritt GJ (2007) Ischemic preconditioning
and intermittent ischemia preserve bile flow in a rat model of
ischemia reperfusion injury. Dig Dis Sci. 52(5):1159-67
Litjens T, Nguyen T, Castro J, Aromataris EC, Jones L, Barritt
GJ, Rychkov GY (2007) Phospholipase C-gamma1
is required for the activation of store-operated Ca2+ channels
in liver cells. Biochem J. 405(2):269-76
Rychkov G, Barritt GJ (2007) TRPC1 Ca(2+)-permeable
channels in animal cells. Handb Exp Pharmacol. (179):23-52.
Review
Prevarskaya N, Zhang L, Barritt G (2007) TRP
channels in cancer. Biochem
Biophys Acta 1772:937-46